Principal Investigators: |
|
| Dr. rer. med. Nora Klöting | Prof. Dr. med. Michael Stumvoll |
| Integrated Research and Treatment Center (IFB) "AdiposityDiseases" | Endocrinology and Nephrology Clinic |
| Universität Leipzig | Universität Leipzig |
| Liebigstraße 21 | Liebigstraße 20 |
| 04103 Leipzig | 04103 Leipzig |
| Phone: +49 341 97 13401 | Phone: +49 341 97 13380 |
| Fax: +49 341 97 13409 | Fax: +49 341 97 13389 |
| nora.kloeting@medizin.uni-leipzig.de | michael.stumvoll@medizin.uni-leipzig.de |
Summary of the Subproject:
During the first funding period, in subproject 3 (Heterogenity of Adipose Tissue, Prof. Dr. med. Matthias Blüher), the replication initiating factor 1 (repin1) has been identified as a yet unknown candidate molecule for the development of visceral obesity. In the preliminary work for this subproject, we were able to show the functional role of Repin1 in adipogenesis, regulation of glucose uptake and fat retention in 3T3L1-cells in vitro. Therefore, we generated a repin1 knock out (Repin1KO) mouse to investigate the role of repin1 in the development of obesity and concomitant diseases in vivo. The aim of this subproject is the comprehensive characterization of the Repin1KO mouse and the conditional, liver-specific Repin1 knock out using Albumin-Cre. This subproject will test the hypothesis that Repin1KO mice are protected against obesity and its concomitant diseases and that the liver is an essential organ for Repin1 function.
Publications:
- Kern M, Kovacs P, Fasshauer M, Klöting I, Fitzl G, Blüher M, Stumvoll M, Klöting N. Defizienz des Replikationsinitiator 1 in der Leber führt zur Ausprägung einer Dyslipidämie in vivo. Diabetologie & Stoffwechsel. 2010;5:S20.
- Ruschke K, Illes M, Kern M, Klöting I, Fasshauer M, Schön MR, Kosacka J, Fitzl G, Kovacs P, Stumvoll M, Blüher M, Klöting N. Repin1 maybe involved in the regulation of cell size and glucose transport in adipocytes. Biochem Biophys Res Commun. 2010;400:246-51.